The research of BOLD-fMRI in broca's aphasia resulting from subacute cerebral hemorrhage

LIU Shu-yong; LI Min; ZHANG Xia

Abstract：Objective To explore the functional compensation and reorganization of the Broca’s aphasia resulting from subacute cerebral hemorrhage .Methods In patients’group ,there were 6 cases ,male :female = 2 :1 ,mean ages :41 .5Y ;20 cases of normal healthy volunteers ,male :10 cases ,female :10 cases .The mean ages :38 .5 Y .The right hand was predominant .The task of picture naming was be done .The same regions in two groups would be compared with the inde‐pendent t tests .The experiment data were dealed with AFNI soft ware and analysed with SPSS 20 .0 .Results The lesions located in left insula lobe and the white matter near the left lateral ventricle were found in 6 cases .The activated regions were as following :left inferior frontal gyrus (BA44/45 region) ,compared with the normal group ,the number of acti‐vatated voxels decreased ,while the activatated intensity increased obviously ;right inferior frontal gyrus (RIFG) ,the acti‐vated intensity and the number of voxels of the RIFG had statistical significance compared with the normal group ,P <0.05 ;activated regions were also be seen in right middle frontal gyrus ,superior temporal gyrus and inferior parietal lobe of both sides ,accessory movement region and so on .Conclusion The RIFG (BA44/45) played an important role in the compensation of the Broca’s aphasia resulting from subacute cerebral hemorrhage .