Application of 125 I radioactive particle implantation by CT guidance in treatment of old patients with peripheral lung cancer

ZUO Tai-yang; HU Xiao-kun; LI Zi-xiang

Abstract：Objective To explore the significance and curative effect the CT guided implantation of 125 I radioactive parti‐cles in treatment of old patients with peripheral lung cancer .Methods The data of 18 patients aged 70 to 86 years old , who suffered with peripheral lung cancer and underwent the CT guided percutaneous puncture implantation of 125 I radioac‐tive particles in our hospital from January 2010 to June 2011 ,were retrospectively analyzed in this work .The series of pa‐tients comprised 11 males and 7 females ,all of whom were confirmed by pathology and expected to be survival for a period of more than 6 months .In addition ,they all lost the operating opportunity or were unwilling to surgery .As for the de‐tailed regimen of CT guided percutaneous puncture implantation of 125 I radioactive particles ,in each part ,the implanted ra‐dioactive particle was 12~56 grain in each part ,radiation particle activity was for 26 ,30 ,33 Mbp/per particle ,particle spacing was 0 .5~1 .0 cm ,and the total radioactive activity was 550~1500 Mbp .The implantation was performed accord‐ing to the "uniform implant principle".Results The patients were followed up to observe the control rate of local tumors and survival rate .Following up for 2 months ,CR lesions were found in 13 cases ,PR in 3 cases ,NC in 2 cases ,PD in ze‐ro ,and RR was 88 .9% (16/18) .Following up for 6 months ,CR lesions were found in 15 cases ,PR in 2 cases ,NC in 1 case ,PD in zero ,and RR was 94 .4% (17/18) .Following up for 1 year ,CR lesions were found in 13 cases ,PR in 2 ca‐ses ,NC in zero ,PD in 3 cases ,and RR was 83 .3% (15/18) .The survival rate was 94 .4% (17/18) after one year .With respect to the complications ,aerothorax was found in 5 cases ,hemoptysis in 3 cases ,postoperative infection in 1 case ,and migration of 125 I radioactive seal seed source or exfliation in 1 case .Conclusion Implantation of 125 I radioactive particles for the treatment of peripheral lung cancer in the elderly is safe and less complications .The curative effects achieve the best at 6 months and this approach can be repeated .