The study of metabolize in patients with post-stroke depression using MRS

SUN Yan-bing; FU Hong-chao; YE Jian-ding

Abstract：Objective To explore the value of MRS in the prediction of patients with post‐stroke depression .Methods A group of 51 patients who experienced stroke for the first time and had a good prognosis and 15 healthy volunteers were enrolled in this study .According to the scores by using the DSM‐IV diagnostic criteria for major depressive disorder and the 17‐item hamilton depression rating scale (HDRS) ,the patients with cerebral infarction were classified into 3 groups . We analyzed the association between post‐stroke depression and 1 H‐MRS measurements in unaffected frontal lobes .Single‐voxel proton magnetic resonance spectroscopy (1 H‐MRS) was performed to assess N‐acetylaspartate/creatine (NAA)/Cr , glutamate (Glu)/Cr ,choline (Cho)/Cr ,and myoinositol (mI)/Cr ratios in stroke patients .Results 11 patients (21 .5% ) who met the criteria for depression and 9 patients (17 .6% ) who had a high score for HDRS (> 14) ,but were not de‐pressed ,had a significantly higher Glu/Cr ratio than patients who scored ≤14 on HDRS and control groups ( P<0 .001) . No differences were found in NAA/Cr ,Cho/Cr ,or mI/Cr between the groups after stroke .Conclusion Post‐stroke de‐pression is accompanied by changes in glutamate levels in the frontal lobe .