Evaluation of low dose contrast agent MSCTA in diagnosis of intracranial aneurysms

HUANGZe-he; CHEN Song; ZHONG De-jun; CHEN Guang; MO Shao-wu; HUANG Jing-mao; SU Zan-rui; CHEN Li-jian

Abstract：Objective To evaluate 64 slices MSCTA with low dose contrast agent in diagnosis of intracranial aneurysms . Methods 108 cases with spontaneous subarachnoid hemorrhage were randomly divided into two groups in which odd num‐bers were set in group A and even number in group B .Brain MSCTA were taken on 54 cases of group A with low dose contrast medium using 0 .6 ml (370 mgI/ml)/kg and 54 cases of group B with routine dose contrast medium using 0 .6 ml (370 mgI/ml)/kg .Both group A and B underwent the same CT imaging reconstruction and the same imaging evaluation . Reference in DSA or operation data ,two doses of contrast agents in group A and B ,MSCTA image quality and the diagno‐sis of intracranial aneurysm compliance rates were compared statistically .Results Thirty‐one in 54 cases of group A were found intracranial aneurysms in 35(92 .1% ) ,and missed in 3 .Thirty‐six in 54 cases of group B were found intracranial an‐eurysms in 37(90 .3% ) ,and missed in 4 .The differences of sensitivity ,specificity and accuracy of MSCTA between group A and B were no statistically significant ( P >0 .05) .The biggest diameter of aneurysms in group A and B were 5 .8 mm and 6 .5 mm ,and correlated to DSA or operation data perfectly ( r =0 .968 and 0 .971 ,P<0 .05) .The differences of CT value within artery between group A and B were no statistically significant ( t=2 .978 ,P>0 .05) .The difference of ima‐ging quality and vein pollution evaluation between group A and B were statistically significant ( P <0 .05) .Conclusion The accuracy of low‐dose contrast medium MSCTA in detection of intracranial aneurysms was similar to conventional‐dose contrast medium ,but low‐dose contrast medium MSCTA was less vein pollution ,and therefore being suitable for intracra‐nial aneurysm primary checking ,preoperative and postoperative evaluation .