Application of DCE-MRI in evaluating anti-angiogenesis and anti-tumor effect of Endostar in breast cancer

JIA Qian-xin; ZHOULi-juan; OUYang-lin; XIAOYu-hui; XU Jun-qing

Abstract：Objective To evaluate the application of dynamic contrast‐enhanced MRI in evaluating the anti‐angiogenesis and anti‐tumor effect of endostar in breast cancer .Methods From March 2008 to August 2012 ,60 cases of breast cancer were enrolled in as research subjects and randomly divided into experimental and control group .These two groups were treated with endostar combined with neoadjuvant chemotherapy and neoadjuvant chemotherapy for 3 cycles respectively . All patients underwent MRI examination before and after treatment using MAGNETOM Trio Tim 3 .0 T superconductive MRI scanning system from the SIEMENS company .Dynamic contrast enhanced magnetic resonance imaging was adminis‐tered with Gd‐DTPA on the basis of conventional imaging .The time signal enhancement curve of DCE‐MRI was quantita‐tively analyzed .We compared the changes of tumors in the two groups after treatment and compared dynamic enhanced MRI results with pathologic findings .Results After treatment ,the inhibition ratio of the tumour in the experimental group was (69 .7 ± 6 .2)% ,higher than that in the control group (48 .71 ± 5 .8)% ( P<0 .05) .The MVD of tumor were (3 .7 ± 1 .7) in the experiment group ,and (5 .1 ± 2 .8) in the control group ( P <0 .05) .TIC curve in the experimental group was more smooth ,and lower than that in the control group .Ktrans which reflected vascular permeability of tumor after treatment was lower than that before in both groups ( P < 0 .05) .The experimental group decreased by (0 .32 ± 0.11) ml/min/100cm3 ,and the control group decreased by (0 .140 .08)ml/min/100 cm3 .The decrease in the experimental group significantly was higher ( P <0 .05) .Ve that reflected tumor extravascular extracellular space reduced after treat‐ment ( P <0 .05) ,but the experimental group reduced by (0 .40 ± 0 .14) ,while ,the control group reduced (0 .19 ±0.12) ,and the difference was statistically significant ( P <0 .05) .Conclusion So ,DCE‐MRI can be used as anti‐angio‐genesis therapy efficacy evaluation tools .Moreover Ktrans and Ve can be used as surrogate biomarkers for tumor mi‐crovessel density ,vascular permeability .