Analysis of immunocytochemistry of intraductal proliferative lesions of the breast
FENG Xin-zhi
LIN Xiao-yan
LU Hong
ZHANG Feng-xia
MEI Hong
ZHAO Bin
Abstract：Objective To assess the immunophenotypic characteristics of intraductal proliferative lesions and their clinical significance .Methods Immunocytochemistry was used to determinate the expression of Her‐2 ,P53 ,Ki‐67 ,CAM5 .2 , CK5/6 and P63 in 177 cases of women with nipple discharge who underwent FDS .Results Immunohistochemieal staining showed that CK5/6 and P63 were obviously expressed in glandular epithelial cells of ordinary‐type ductal hyperplasia , while they were lower or not expressed in atypical ductal hyperplasia ,fiat epithelial atypia and ductal carcinoma in situ . Her‐2 ,P53 ,Ki‐67 and CAM5 .2 were expressed more strongly than CK5/6 and P63 in ductal carcinoma in situ ,but were not expressed in ordinary‐type ductal hyperplasia .Conclusion The abnormal expression of Her‐2 ,P53 ,Ki‐67 ,CAM5 . 2 ,CK5/6 and P63 may be an early event in the progression of breast carcinoma ,and combined detection of them could be used for early diagnosis of breast cancer .
Keywords：BreastIntraductal proliferative lesionImmunocytochemistry
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1907-1910,1926 )