Study of resting-state functional MRI in motor aphasia after Ischemic stroke

LIU Hui-ru; WANG Wei-zhuo; WANG Xin; TAO Jie-jie; WEN Cai-yun; WANG Han-min; CHENG Jian-hua; XU Hui-qin; CAOGuo-quan; WANG Mei-hao; LI Jian-ce

Abstract：Objective To investigate the changes of amplitude of low-frequency fluctuation (ALFF) and functional con-nectivity (FC) in ischemia stroke motor aphasia patients with resting-state functional magnetic resonance imaging (RS-fM-RI) ,and to discuss underlying neurophysiological mechanism of the disease .Methods Using 3 .0 T MRI scanner ,Pa-tients with ischemia stroke motor aphasia and normal controls experienced resting-state fMRI scans .The difference of ALFF between two groups was analyzed with two-sample t test ;Significant differences of connectivity between groups were acquired to calculate the functional connectivity of left posterior cingulate gyrus with other brain region controls .Re-sults Compared with controls ,patients showed significantly decreased ALFF in left cerebellum anterior lobe ,fusiform gyrus ,left posterior cingulate gyrus ,and left medial frontal gyrus .Regions whose ALFF increased included right cingu-late gyrus .Compared with controls ,the brain region functional connectivity correlated with left posterior cingulate gyrus reduced mainly located in the left medial frontal gyrus ,left middle temporal gyrus ,Left thalamus ,Right middle/inferior frontal gyrus ,right precentral gyrus ,right postcentral gyrus ,right middle temporal gyrus ,right middle occipital gyrus , right parahippocampal gyrus ,bilateral precuneus ,posterior cingulate gyrus ,splenium of corpus callosum ;regions whose FC increased included left cerebral hemispheres ,left cerebellar dentate nuclei ,the left cerebellum ,right orbital gyrus/rec-tal gyrus ,right cerebellum posterior lobe ,and right brainstem ( P < 0 .001 ,Alphasim corrected) .Conclusion In the resting state ,the combination of both ALFF and FC methods can be better and more complete from the perspective of local and global evaluation of the brain activities .Our work will facilitate the understanding of the pathogenesis of cerebral mot-o r aphasia .