Correlation study between vascular conditions and perfusion status in unilateral moyamoya disease

ZHA NG Ya-Nan; XUE Jing; GAO Pei-Yi

Abstract：Objective To investigate the correlation between vascular conditions in the territory of middle cerebral artery (MCA) and perfusion status with unilateral moyamoya disease (MMD) .The study may provide an objective base for a more individualized assessment of hemodynamic status .Methods A restrospective analysis of 31 patients with single MCA involvement in unilateral MMD ,whose diagnoses were confirmed in Tiantan Hosipital between 2008 and 2013 ,was performed .The relationship among the degree of MCA stenosis ,collateral grading and relative perfusion parameters in the M1-M6 regions of MCA cortex was performed .Spearman rank correlation test and multiple linear regression were used in the statistical analysis .Results ① The correlation between the degree of MCA stenosis and perfusion parameter map:rCBF positively correlated with the degree of MCA stenosis ,and rMTT ,rTTP negatively correlated with the degree of MCA stenosis in all regions except for rCBF in the M3 region and all relative perfusion parameters in the M4 region;②The correlation between collateral grading and perfusion parameter map:collateral grading negatively associated with rCBV in the M5 region ,rCBF and rCBV in the M6 region ,and positively associated with rMTT in the M1 region ,rMTT and rTTP in the M6 region;③ Other factors :age was also independent factor that decreased rCBF ,prolonged rMTT and rTTP in the M3 region .Conclusion Degree of MCA stenosis ,collateral grading and age were important factors influen-cing relative perfusion parameters in all regions in unilateral MMD patients .