Treatment of recurrent malignant tumor in paranasal sinuses with radioactive particle 125 I implantation by CT guidance

WA NG Qi-feng; ZUO Tai-yang; HU Xiao-kun

Abstract：Objective To investigate the method ,efficacy and safety of radioactive particle 125 I implantation by CT guid-ance in treatment of recurrent malignant tumor in paranasal sinuses .Methods 11 cases of recurrent malignant tumor in paranasal sinuses were subjected to percutaneous implantation of radioactive particle 125 I under the CT guidance .Preopera-tively ,the lesion contour and size were ovbserved by use of radioactive seed brachytherapy treatment planning system (brachy interstitial-therapy planning system ,BI-TPSTM ) .The radioactivity and dosage of particle 125 I were calculated . The prescription dose (prescribed dose ,PD) was 110~140 Gy and particle activity was 0 .6~0 .8 mCi .Postoperatively , CT scan was immediately performed and the quality was validated .The regular CT cllow-up was conducted to determine curative effect .Results 11 patients with maxillofacial recurrent malignant tumors were completely accepted the treatment planning and underwent CT re-examination at 2 months ,4 months ,6 months ,and 12 months after operation ,respective-ly .The local tumor control rate (RR) was 100% (11/11) ,100% (11/11) ,90 .9% (10/11) ,81 .8% (9/11) in order of the indicated time points .3 cases appeared obvious ossification in destroyed bone area at the implanted site ,accounting for 27.3% (3/11) .One patient was implanted once more 6 months later .6 patients appeared skin pigmentation one month af-ter the treatment .Conclusion Radioactive particle 125 I implantation guided by CT is simple ,reliable curative effect ,high safety in treatment of recurrent malignant tumor in paranasal sinus .It is worthy for further application research .