The correlation of DTI parameters and Gleason scores of prostate cancer：a pilot study
GONG Tao
YUAN Shu-hui
LI Li-li
LIU Qiang
WANG Bin
Abstract：Objective To investigate the relationship between ADC and FA values ,the quantitative parameters of DTI of prostate cancer ,and Gleason score .Methods DTI was performed in 65 cases of prostate cancer confirmed by biopsy or surgical pathology .ROI was drawn on the map fused DTI with T2WI to measure the ADC and FA values of the corre-sponding area in biopsy .The correlation between the ADC-FA values and Gleason score was analyzed .Then the 65 cases of prostate cancer were divided into three groups :low ,intermediate and high grade ,according to the Gleason score .The ADC and FA values of each group were measured and analyzed .Results The ADC and FA values of prostate cancer were all negatively related with Gleason score ( r=-0 .731 ,P<0 .05 ;r=-0 .606 ,P<0 .05) .ADC values of low ,intermediate and high grade prostate cancer were (961 ± 103)× 10-6 mm2/s ,(770 ± 152)× 10-6 mm2/s and (652 ± 111)× 10-6 mm2/s;FA values were (395 ± 60)× 10-3 ,(313 ± 93) × 10-3 and (235 ± 64)× 103 respectively .The difference among three groups of ADC and FA values were all statistically significant ( P < 0 .05) .Conclusion The ADC and FA values of prostate cancer were negatively correlated with Gleason score ,ADC and FA values could be used to evaluate the grading and prog-nosis of prostate cancer .
Keywords：Prostate neoplasmsMagnetic resonance diffusion weighted imagingApparent diffusion coefficientThe anisotropyGleason score
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 574-577 )