CT imaging findings of renal cell carcinoma associated with Xp 11 .2 translocation/TFE3 gene fusions
JIANG TIAN-JIAO
YANG qing
DUAN Chong-feng
LIN dong-liang
Abstract：Objective To investigate the clinical ,pathological and imaging features of the renal cell carcinoma associated with Xp11 .2 translocation /TFE3 gene fusions ,so as to help to diagnosis before surgery .Methods The clinical ,patho-logical and imaging features of five cases were retrospectively analyzed ,and the related literatures were reviewed .Results The mean age was 35 years(range ,10~61 years) .Four cases were women .ALL of the five cases were hypovascular on contrast-enhanced CT and comprised of solid lesion with focal necrosis and hemorrhage ,four cases were calcified ,two ca-ses were adrenal metastasis ,four cases were lymph node metastasis .Tumor cells had the nest structure and papillary structure ,eosinophilic granula cells and psammoma bodies can be seen .All of TFE3 was positive .Conclusion Renal car-cinoma associated with Xp11 .2 translocation /TFE3 gene fusions is rare ,the possibility of this tumor should be consid-ered a renal mass seen in a young patient ,which demonstrates hemorrhage or necrosis on unenhanced CT ,slight enbance-ment on contrast-enhanced CT ,lymph node and distant organ metastasis .
Keywords：Xp11 .2T FE3Renal carcinomaImaging findings
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 549-552 )