The mechanism and clinical application of ferroptosis in head and neck cancer
LI Bin
XU Fang
MA Ruixia
LIU Peng
Abstract：Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation.By modulating iron metabolism,lipid peroxidation,and antioxidant defense systems,ferroptosis can effectively induce tumor cell death and suppress tumor proliferation and metastasis.Emerging research indicates that head and neck cancer(HNC)cells can evade ferroptosis by upregulating the expression of SLC7A11.Consequently,researchers have developed various ferroptosis inducers and explored their therapeutic potential in HNC.Notably,combining these inducers with chemotherapeutic agents or immune checkpoint inhibitors has been shown to significantly enhance antitumor efficacy.However,the specific regulatory mechanisms of ferroptosis across different HNC subtypes and their clinical applications require further investigation.This article reviews recent advances in the molecular mechanisms,regulatory networks,and clinical applications of ferroptosis in HNC,to provide insights for future research and accelerate its clinical translation.
Keywords：FerroptosisHead and neck cancerMolecular mechanismsClinical applicationsTherapeutic strategies
Publication Date：2026-02-25
Online Publishing Date：2026-03-26(First online date of this platform, not the publication date of the document)
Pages：6( 211-216 )