Research progress on the role of microRNA in epithelial-mesenchymal transition of colorectal cancer
ZHANG Tao
LI Huilong
FENG Jing
CHEN Miao
Abstract：Colorectal cancer(CRC)is the third most common cancer globally,with an incidence rate ranked just behind lung cancer and breast cancer in women.Epithelial-mesenchymal transition(EMT)enhances the migratory and invasive abilities of tumor cells but is also closely associated with tumor recurrence and drug resistance.MicroRNAs(miRNAs)are a class of non-coding RNAs that regulate the EMT process through various mechanisms and pathways.Therefore,this review aims to summarize the roles and research progress of miRNAs in the regulation of EMT in CRC,providing new insights into the complex regulation of EMT and offering potential strategies for the prevention and treatment of CRC metastasis.
Keywords：Colorectal cancerEpithelial-mesenchymal transitionMicroRNADrug resistanceNatural compound
Publication Date：2026-01-25
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：7( 103-109 )