The research progress of fibroblast growth factor 21 in retinal neovascularization diseases
SHI Ruobing
ZHU Fangyuan
LIU Hang
XIAO Xuan
YANG Anhuai
Abstract：Retinal neovascularization(RNV)diseases are one of the leading causes of visual impairment and blindness,including diabetic retinopathy,retinopathy of prematurity,retinal vein obstruction,and wet age-related macular degeneration.In recent years,fibroblast growth factor 21(FGF21),a multifunctional metabolic regulator,has been found to exert a significant inhibitory effect on RNV.Therefore,this article systematically reviews the biological characteristics of FGF21,its molecular regulatory mechanisms in RNV diseases,and its potential therapeutic applications,aiming to provide a theoretical basis for developing novel FGF21-based treatment strategies for retinal diseases.
Keywords：Fibroblast growth factor 21Retinal neovascularizationDiabetic retinopathyRetinopathy of prematurityAge-related macular degenerationRetinal vein obstruction
Publication Date：2026-01-25
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：6( 97-102 )