Research progress on epigenetic regulation in cognitive impairment of offspring caused by stress during pregnancy
CHANG Qing
ZHI Jincao
JIA Xueyan
LIU Yan
XU He
JI Weiwei
WANG Yan
Abstract：With social development and increased life pressures,prenatal stress has become a significant physical and mental challenge for women during the perinatal period.Research indicates that prenatal stress may affect fetal developmental programming through epigenetic regulatory mechanisms,thereby interfering with neurodevelopment and increasing the risk of emotional disturbances,behavioral abnormalities,and cognitive impairments in offspring.Epigenetic modifications such as DNA methylation(DNAm),histone modifications,and non-coding RNAs(ncRNAs)are likely to mediate the long-term effects of prenatal stress on offspring cognitive function.This article summarizes the mechanisms of epigenetic regulation in prenatal stress-induced cognitive impairments in offspring,with a focus on analyzing the associations of DNAm,histone modifications,and ncRNAs with cognitive deficits in offspring,aiming to provide references for the development of relevant clinical intervention strategies.
Keywords：Prenatal stressEpigeneticsCognitive impairmentDNAmHistone modificationsncRNAs
Publication Date：2025-12-25
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：6( 1477-1482 )