Meta-analysis of the efficacy and safety of long-term low-dose clarithromycin in the treatment of chronic rhinosinusitis
WANG Yahua
HUANG Chuansheng
ZHANG Zhihui
GUO Xinhong
PENG Xi
Abstract：Objective To systematically evaluate the efficacy and safety of long-term low-dose clarithromycin in the treatment of chronic rhinosinusitis(CRS).Methods Randomized controlled trials(RCTs)of low-dose clarithromycin for CRS were collected from CNKI,WanFang,VIP,PubMed,Embase,Web of Science,The Cochrane Library databases,and the clinical trial registration platform from database inception to January 21,2025.Meta-analysis was performed by RevMan 5.4.1 software.Results A total of 31 RCTs were included.The treatment group showed superior results compared to the control group in terms of overall effectiveness[OR=4.31,95%CI(3.30,5.63)],SNOT-20 scores[MD=-1.64,95%CI(-3.20,-0.08)],Lund-Kennedy scores[MD=-1.17,95%CI(-1.55,-0.79)],Lund-Mackay score[MD=-1.38,95%CI(-1.84,-0.92)],and VAS scores[MD=-1.11,95%CI(-1.50,-0.72)],with statistically significant differences(P<0.05).However,there was no statistically significant difference between the two groups in terms of adverse event rate[OR=1.12,95%CI(0.74,1.70)]and recurrence rate[OR=0.73,95%CI(0.39,1.37)](P>0.05).Conclusion Current evidence suggests that long-term low-dose clarithromycin treatment for CRS has good clinical efficacy,though further validation through high-quality,large-scale RCTs remains necessary.
Keywords：Chronic rhinosinusitisLow-dose clarithromycinSafetyEfficacyMeta-analysis
Publication Date：2025-11-25
Online Publishing Date：2025-12-16(First online date of this platform, not the publication date of the document)
Pages：8( 1347-1354 )