The relationship between depression,sarcopenic obesity and the risk of stroke in Chinese middle-aged and older adults

SUN Yao; NIU Chunxiao

doi:10.12173/j.issn.1004-5511.202412118

Abstract：Objective Investigating the relationship between the interactive and combined effects of depression and sarcopenic obesity(SO)and the risk of stroke in Chinses middle-aged and older adults.Methods Based on the China Health and Retirement Longitudinal Study(CHARLS)data,middle-aged and older people who participated in the three surveys in 2015,2018 and 2020 were selected.The Kaplan-Meier cumulative incidence curve was used to analyze the cumulative incidence risk among subjects in different groups.Cox proportional hazards regression models were employed to separately examine the associations between depression and SO,and their interaction,and combined effects with the risk of stroke in middle-aged and older individuals.Sensitivity analyses were conducted to validate the robustness of the results.Results A total of 10,694 study participants were enrolled in this study,and a total of 698(6.53％)of them experienced stroke during the 5-year follow-up period.Results showed that after adjusting for confounding factors including gender,age,education level,and marital status,compared with the control group,the risk of stroke increased by 52％[HR=1.52,95％CI(1.28,1.81)]in the depression group and 47％[HR=1.47,95％CI(1.08,1.99)]in the SO group respectively.No interaction effect was observed between depression and SO,but a significant combined effect was identified.Compared with the non-depressed-normal group,the depressed-SO group exhibited a 126％[HR=2.26,95％CI(1.51,3.38)]increased risk of stroke.Conclusion The combined effect of depression and SO significantly increases the risk of stroke in middle-aged and older individuals.Enhanced psychological counseling,nutritional guidance,and exercise training should be provided to this population to reduce their risk of stroke.