Analysis of the predictive value of event-related potential contingent negative variation combined with cognitive function indicators for chronic schizophrenia

JIANG Kai; WANG Dan; HAN Lu; KANG Zhaopeng; YANG Xuna

doi:10.12173/j.issn.1004-5511.202408045

Abstract：Objective To analyze the predictive value of event-related potential(ERP)contingent negative variation(CNV)induced by dot pattern expectancy(DPX)and cognitive function indicators in chronic schizophrenia(CS).Methods Behavioral data of all subjects were collected using DPX,CNV waves based on DPX task-induced events were performed on the patients,and the cognitive function of all subjects was assessed using MATRICS set of recognized neurocognitive function tests.Pearson correlation was used to analyze the correlation among behavioral data,CNV amplitude and cognitive function.The receiver operating characteristic(ROC)curve and the area under the curve(AUC)to evaluate the predictive value of CNV index combined with cognitive function indicators for CS.Results A total of 110 subjects were included,comprising 50 CS patients as the study group and 60 participants from health checkups as the control group.The error rate of ERP task EAX,EAY and EBX in the study group was higher than that in the control group,and EBX-AY was lower than that in the control group.The continuous operation 2D,continuous operation 3D,continuous operation 4D,continuous mean,connection test,maze test,symbol coding score and the absolute value of CNVA,CNVB and CNVB-A amplitude of CP3,CP4,CPZ sites,and the absolute value of CNVB-A amplitude of CP3 sites in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).In the study group,CP3 site CNVA and EBX-AY,CNVB-A and EAX,EBX,EBX-AY and continuous operation 2D were positively correlated,EAY and continuous operation 2D,continuous mean,EBX and continuous operation 3D,line test,symbol coding were negatively correlated,CP3 site CNVA was positively correlated with EAY and EBY,CPZ site CNVA and EBY,CPZ site CNVA and continuous operation 2D,CPZ site CNVB and wired test were negatively correlated in the study group,and the above comparisons were statistically significant(P＜0.05).ROC curve analysis showed that the AUC values of continuous operation 2D,continuous operation 3D,continuous operation 4D,continuous mean,maze test and symbol coding score amplitude diagnostic CS were greater than 0.7,which were 0.826,0.838,0.773,0.875,0.870 and 0.933,respectively.Conclusion The CNV wave amplitude induced by the DPX task is correlated with the cognitive function of CS patients.It can be used as an objective neurophysiological index to evaluate the degree of cognitive function impairment in CS patients,providing a theoretical basis for the guidance and treatment of CS in the future.