The disease burden of infertility in China from 1992 to 2021 based on an age-period-cohort model
HUANG Bingyi
ZHAO Qin
YAO Libo
WANG Manyi
ZHAO Qianwen
Abstract：Objective To analyze the disease burden of infertility in China from 1992 to 2021.Methods Data for this study were derived from the 2021 Global Burden of Disease Study.Joinpoint regression model was used to analyze the prevalence and disability-adjusted life-year(DALY)rate of infertility in China and their average annual percentage change(AAPC)to assess the changing trend of the disease.Age-period-cohort models were used to explore age,period,and cohort effects.Results From 1992 to 2021,the prevalence of infertility decreased for both men[AAPC=-0.39％,95％CI(-0.43％,-0.35％)]and women[AAPC=-0.39％,95％CI(-0.40％,-0.32％)].The DALY rate also decreased for both men[AAPC=-0.41％,95％CI(-0.46％,-0.38％)]and women[AAPC=-0.41％,95％CI(-0.44％,-0.37％)].Age-effect results showed that the prevalence and DALY rates of infertility in both men and women in China increased first and then decreased with age from 1992 to 2021.Period-effect results showed that the risk of infertility and DALY risk decreased for both men and women in China from 1992 to 2021.Cohort-effect results showed that later birth cohorts had lower risks of infertility and DALYs.Conclusion From 1992 to 2021,both the prevalence and DALY rates of infertility in China showed a downward trend,with later birth cohorts exhibiting lower risks.Targeted prevention and treatment efforts for different age groups and the active promotion of assisted reproductive technologies can reduce the burden of infertility in China.
Keywords：InfertilityBurden of diseasePrevalenceAge-period-cohort model
Publication Date：2025-09-25
Online Publishing Date：2025-11-10(First online date of this platform, not the publication date of the document)
Pages：7( 1041-1047 )