A case report on chemotherapy-free treatment for small cell lung cancer
XUE Jingyi
WANG You
ZHOU Fuxiang
Abstract：The standard treatment regimen for small cell lung cancer(SCLC)relies on platinum-based systemic chemotherapy.However,its high toxicity and limited long-term efficacy have driven clinical researchers to explore chemotherapy-free or de-chemotherapy strategies.This case reports an elderly patient with limited-stage SCLC who achieved sustained partial response(PR)without receiving systemic chemotherapy.The patient underwent staged hypofractionated radiotherapy combined with immunotherapy(sintilimab)and targeted therapy(surufatinib),resulting in a disease-free survival of 11 months without significant toxic side effects.This case highlights the potential advantages of a chemotherapy-free approach in SCLC treatment and provides valuable clinical insights into optimizing therapeutic strategies for enhanced efficacy with reduced toxicity.
Keywords：Small cell lung cancerChemotherapy-freeRadiotherapyImmunotherapyTargeted therapy
Publication Date：2025-08-25
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：6( 974-979 )