Relationship between the ratio of non-HDL-C and HDL-C and the risk of all-cause mortality in a population with abnormal glucose metabolism:base on CHARLS database
ZHANG Jie
FANG Kui
CHEN Hongyan
Abstract：Objective To investigate the relationship between non-high-density lipoprotein cholesterol(non-HDC-L)to high-density lipoprotein cholesterol(HDC-L)ratio(NHHR)and the risk of all-cause mortality in the population with abnormal glucose metabolism,and to provide a scientific basis for lipid management in patients with abnormal glucose metabolism.Methods Based on the 2011-2018 data of the China Health and Retirement Longitudinal Study,the relationship between NHHR and all-cause mortality risk was analyzed by restricted cubic spline and Cox proportional risk regression modeling in a population with abnormal glucose metabolism(including prediabetic and diabetic patients).Results A total of 6,300 study participants were enrolled,with 685 deaths during the 7-year follow-up period.The significant U-shaped nonlinear relationship was observed between NHHR and the risk of all-cause mortality in the population with abnormal glucose metabolism,with an inflection point value of 3.03(nonlinear P=0.006).Each unit increase in NHHR was associated with a 21％reduction in the risk of all-cause mortality when NHHR＜3.03[HR=0.79,95％CI(0.65,0.95)],and a 5％increase in the risk of all-cause mortality when NHHR≥3.03[HR=1.05,95％CI(1.01,1.08)].Stratified analysis of NHHR tertiles showed that the middle tertile group(Tertile 2)had the lowest risk of all-cause mortality,and that both the lower tertile group(Tertile 1)and the higher tertile group(Tertile 3)had a significantly increased risk of mortality compared with the Tertile 2 group,with HRs of 1.26[95％CI(1.05,1.52)]and 1.23[95％CI(1.01,1.49)].Conclusion There was a significant U-shaped nonlinear relationship between NHHR and the risk of all-cause mortality in the population with abnormal glucose metabolism.
Keywords：Non-high density lipoprotein cholesterolHigh density lipoprotein cholesterolNHHRAbnormal glucose metabolismDyslipidemiaRisk of all-cause mortalityCohort studies
Publication Date：2025-08-25
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：7( 878-884 )