The role of zinc homeostasis in prostate diseases and potential mechanisms
HAN Yutong
FAN Jiuming
WANG Tiankun
QI Zihao
ZHANG Yuanyuan
HOU Junqing
Abstract：Zinc is an essential trace element in the human body,participating in various critical physiological functions and being highly concentrated in the prostate gland.Studies have shown that prostate diseases might be associated with zinc imbalance.Investigating the regulatory mechanisms and dynamic patterns of zinc homeostasis in prostate diseases holds significant importance for exploring the pathogenesis,progression mechanisms,and zinc homeostasis-based prevention and treatment strategies for prostate disorders.Building on a synthesis of previous evidence,this review elaborates on the maintenance processes and key regulatory factors of zinc homeostasis in the human body,and provides an in-depth analysis of zinc's role in the development and progression of prostate diseases,along with potential underlying biological mechanisms.
Keywords：ZincZinc HomeostasisProstatic diseasesProstate cancerBenign prostatic hyperplasia
Publication Date：2025-07-25
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：9( 846-854 )