Molecular mechanisms of ferroptosis in Alzheimer's disease and breakthroughs in targeted therapeutics:translational advances from bench to bedside
WANG Younian
LIU Qiangsheng
MENG Kun
ZHOU Lanting
WANG Lu
YE Fan
Abstract：Alzheimer's disease(AD)is a kind of neurodegenerative disease that seriously endangers human health.Although there are many hypotheses about the cause and progression of AD,the mechanism of action is still poorly understood.In recent years,ferroptosis,as a unique mode of cell death,has attracted attention due to its iron-dependent lipid peroxidation characteristics,and is widely present in the brain tissue of AD.More and more evidence show that ferroptosis is closely related to the occurrence,development and prognosis of AD.This article reviewed the main mechanism of ferroptosis mediating the occurrence of AD and the research progress in the treatment of AD,aiming to provide a solid theoretical basis for the clinical research of AD and a new strategy of targeted therapy.
Keywords：Alzheimer's diseaseFerroptosisIron dyshomeostasisLipid peroxidationCystine/glutamate antiporter system
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 697-707 )