Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer
CHEN Wangcheng
PANG Lili
LAN Yuemei
ZHANG Baihong
Abstract：This paper explores the multiple roles of oncostatin M(OSM)in the breast cancer microenvironment.OSM enhances invasion and metastasis of breast cancer cells by activating the JAK/STAT pathway,promoting epithelial-mesenchymal transition,cancer-associated fibroblast activation,and immune escape,especially in bone and lung metastasis.OSM also works synergistically with matrix metalloproteinases to accelerate cancer progression.Although OSM is a potential therapeutic target,its pleiotropic nature presents a therapeutic challenge.Future studies are needed to develop more selective and safe OSM inhibitors,combined with other therapeutic strategies to improve efficacy.
Keywords：Breast cancerOncostatin MTumor microenvironmentTumor metastasis
Publication Date：2025-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 339-344 )