Analysis of the disease burden of neonatal encephalopathy due to birth asphyxia and trauma in China from 1990 to 2019
HUANG Zirui
CHENG Yan
CHEN Guo
YANG Min
Abstract：Objective To analyze the disease burden and its trend of neonatal encephalopathy due to birth asphyxia and trauma in China from 1990 to 2019.Methods From the Global Burden of Disease Study 2019,data about disability-adjusted life years(DALYs),DALY rates,mortality,mortality rates and risk factors for neonatal encephalopathy due to birth asphyxia and trauma in China from 1990 to 2019 were extracted.The Joinpoint regression analysis was employed to calculate the annual average percentage change(AAPC)and 95％confidence intervals(CI)of mortality rate and DALY rate.Results In 2019,the mortality rate for neonatal encephalopathy due to birth asphyxia and trauma in China was 1 139.527 people per 100 000,and the DALY rate was 101 275.239 person years per 100 000,both of which had decreased by 76.23％compared to 1990.Among which,the mortality rates for male and female neonates were 1 230.738 people per 100 000 and 1 033.004 people per 100 000,respectively,and DALY rates were 109 381.824 person years per 100 000 and 91 807.766 person years per 100 000,respectively;the mortality rates for neonates aged 0 to 6 days and 7 to 28 days were 4 022.626 people per 100 000 and 178.166 people per 100 000,respectively,and DALY rates were 357 481.444 person years per 100 000 and 15 844.063 person years per 100 000,respectively.The AAPC for mortality rate and DALY rate from 1990 to 2019 was both-4.88[95％CI(-5.17,-4.59)].Small than gestational age,premature birth,environmental particulate pollutants,and household pollution from solid fuel combustion were the main risk factors for neonatal encephalopathy caused by birth asphyxia and trauma in China.Conclusion Compared to 1990,the mortality rate and DALY rate for neonatal encephalopathy due to birth asphyxia and trauma in China in 2019 showed a declining trend.The disease burden for male children in the early neonatal period was higher than that for female children.Policies should be formulated to address factors such as being small gestational age,preterm birth,ambient particulate matter pollution,and household pollution from the burning of solid fuels,and to continue to focus on prenatal care services,with the aim of reducing the disease burden of neonatal encephalopathy due to birth asphyxia and trauma.
Keywords：Neonatal encephalopathyBirth asphyxiaTraumaJoinpoint regression analysisDisease burden
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 843-851 )