Research progress of hyperuricemia in the pathogenesis of diabetic peripheral neuropathy
SHEN Gege
ZHOU Jie
FU Jianfang
WANG Li
LI Xiaomiao
Abstract：Diabetic peripheral neuropathy(DPN)is one of the common chronic complications of diabetes,which seriously affects the life quality of diabetic patients.Therefore,early clinical diagnosis is very important for the prevention and treatment of DPN.Hyperuricemia is a metabolic disease caused by purine nucleotide metabolism disorder.Although a large number of studies have shown that the hyperuricemia may be an independent risk factor for DPN,its potential effects on DPN and mechanisms of action have not been fully elucidated.This paper summarizes the pathogenesis of DPN,introduces the role of uric acid in the pathogenesis of DPN,and expounds that oxidative stress and inflammation are the roles of hyperuricemia in the pathogenesis of DPN,so as to provide references for finding early clinical warning indicators.
Keywords：Diabetic peripheral neuropathyHyperuricemiaReactive oxygen speciesInflammation
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 466-472 )