Research progress on the role and mechanism of oxidative stress in spinal cord injury
MA Chunwei
ZHANG Haihong
Abstract：Spinal cord injury(SCI)is a disease that profoundly impacts the central nervous system,with oxidative stress playing a crucial role in its secondary damage.This article provides a comprehensive review of the role of oxidative stress in SCI,its primary signaling pathways,and current treatment methods.It focuses particularly on the functions of pathways such as Nrf-2,PI3K/AKT,and TLR4/MyD88 in the regulation of oxidative stress and explores the potential of antioxidant therapies in alleviating SCI symptoms.This paper aims to offer insights for a deeper understanding of SCI and provide reference for optimizing treatment strategies.
Keywords：Spinal cord injuryOxidative stressSignaling pathwayReactive oxygen
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 339-346 )