Antioxidant Effects of High-density Lipoprotein in Patients with Atherosclerosis

Abstract：Objective To explore antioxidant effects of paraoxonase-1(PON-1)on high-density lipoprotein(HDL)in patients with coronary heart disease(CHD)in order to provide experimental evidences for explaining molecular mechanisms of AS and prevent AS.Methods Blood samples of 199 patients with CHD were collected as CHD group including 104 patients with low level HDL-C and 95 patients with normal level HDL-C.Blood samples of 100 healthy persons were collected as control group including 22 healthy persons with low level HDL-C and 78 healthy persons with normal level HDL-C.PON-1 activity and blood lipid indexes were tested.Results PON-1 activity was lower in people with low level HDL-C than those with normal level HDL-C(P<0.01).There was no significant difference on PON-1 activity between CHD patients with normal level HDL-C and healthy persons with low level HDL-C(P >0.05).However,PON-1/apoA-I ratio was lower in CHD patients with normal level HDL-C(P<0.01).Conclusion Patients with CHD may have abnormal HDL antioxidant effects with significant decrease of PON-1 activity.PON-1/apoA-I ratio can be used as a good evaluating index for HDL antioxidant effects in patients with CHD.