The Diagnostic Value of Blood β2 - microglobulin and Cystatin - C in Early Kidney Impairment after Neonatal Asphyxia

Abstract：Objective To analyze the clinical diagnostic value of β2 - microglobulin(β2 - MG)and Cystatin -C(CysC)in early Kidney impairment after neonatal asphyxia. Methods 36 newborns with severe asphyxia and 114 mild asphyxia were chosen as the observation group,and 150 newborns without neonatal asphyxia were chosen as the control group. The levels of serum β2 - MG,Cys - C,BUN and Cr were detected within 2 hours after birth. The four indicators were compared between groups and within groups. Results There were no significant differences in serum levels of β2 - MG,Cys - C,BUN and Cr in newborns of different gestational age. Serum levels of β2 - MG and Cys -C were significantly higher in neonatal asphyxia group than those in control group(P < 0. 01). Serum levels of β2 -MG and Cys - C were significantly higher in severe asphyxia group than those in mild asphyxia group(P < 0. 01). Ser-um levels of β2 - MG and Cys - C were significantly higher in mild asphyxia group than those in control group(P <0. 05). There were no significant differences in BUN and Cr among three groups. Serum levels of β2 - MG and Cys -C in neonatal asphyxia group were positively correlated(r = 0. 321,P < 0. 01). AUC of serum β2 - MG(0. 786)and Cys - C(0. 695)were both larger than those of BUN(0. 568)and Cr(0. 555)in ROC curves analyzing implications of different indicators for severe asphyxia. Conclusion Serum β2 - MG and Cys - C are better marKers than serum BUN and Cr to detect early Kidney damage after neonatal asphyxia,and provide basis for clinical decision - maKing as well as predicting the prognosis.