Target Controlled Infusion of Dex,edeto,idine Co,bined with Propofol for Painless Colonoscopy on Elderly Patients

Xu Hongshuang; Li Dapeng; Zhang Zongze

Abstract：Objective To evaluate clinical effects of target controlled infusion of dexmedetomidine combined with propofol for painless colonoscopy on elderly patients. Methods 100 elderly patients underwent painless colonos-copy were randomly divided into control group and observation group. Target controlled infusion of propofol was per-formed in control group,while dexmedetomidine was added in the observation group. Induction time,recovery time and dose of propofol were observed and recorded. Hemodynamic parameters were monitored. Pain assessment was per-formed using visual analogue scale(VAS). All the data were statistically analyzed and compared. Results The induc-tion time,recovery time,and dose of propofol in observation group were significantly less than those in control group (P < 0. 05). HR and MAP at T1 in two groups were significantly decreased compared with those at T0(P < 0. 05). HR and MAP at T2 in two groups were significantly increased compared with those at T1(P < 0. 05). HR and MAP at T2 and T3 in observation group were significantly lower than those in control group(P < 0. 05). VAS score in observation group(1. 8 ± 0. 5)was significantly lower than that in control group(4. 2 ± 0. 9)(P < 0. 05). Conclusion Target con-trolled infusion of dexmedetomidine combined with propofol for painless colonoscopy on induction of anesthesia in eld-erly patients has several advantages such as short induction time,rapid recovery,less propofol dose with good analgesic effect. However,hemodynamic monitoring should be strengthened.