Expression of P16,P21,P53 and NF - κB P50 in Hepatocellular Carcinoma and Their Clinical Significance

Liu Huan; Yang Guifang

Abstract：Objective To explore the expression of P16,P21,P53 and NF - κB P50 in hepatocellular carcinoma (HCC)and their clinical significance. Methods The expression of P16,P21,P53 and NF - κB P50 in tissue chips from 57 cases of HCC and 27 cases of normal liver tissue were examined by immunohistochemical staining. Their cor-relations with differentiation degrees of HCC were analyzed. Results Expressions of P16 and P21 were significantly lower in HCC tissues than those in normal tissues(P = 0. 039 and P = 0. 024,respectively). Expressions of P53 and NF - κB P50 were significantly higher in HCC tissues than those in normal tissues(P = 0. 003 and P = 0. 028,respec-tively). Expressions of P16 and P21 were positively associated with differentiation degrees. Negative expression rate of P16 and P21 were high in low - differentiation HCC(P = 0. 033 and P = 0. 020,respectively). Expressions of P53 and NF - κB P50 were negatively correlated to differentiation degrees of HCC. Positive expression rate of P53 and NF - κB P50 were high in low - differentiation HCC(P = 0. 033 and P = 0. 013,respectively). Conclusion Combined detec-tion of P16,P21,P53 and NF - κB P50 has a certain clinical significance in diagnosis and identification of differentia-tion degree in HCC.