The Effect of Small - dose Dexmedetomidine or Fentanyl on Cardiovascular Response during Extubation

Abstract：Objective To observe the prevention effects of cardiovascular response during tracheal extubation by a small dose of dexmedetomidine or fentanyl. Methods 60 ASA Ⅰ ~ Ⅱpatients were randomly divided into control group(n = 20),dexmedetomidine group(n = 20)and fentanyl group(n = 20). Combined general anesthesia of intra-venous and inhalation was performed in all patients without opioid receptor antagonist awakening. 0. 3 μg/ kg dexme-detomidine was pumped intravenously before extubation in dexmedetomidine group. 1 μg/ kg fentanyl was injected in-travenously before extubation in fentanyl group. No drug was given before extubation in control group. Heart rate (HR)and mean arterial pressure(MAP)were observed before medication,before extubation,1 min after extubation, 5 min after extubation and 10 min after extubation. Results HR was significantly decreased after medication in dexmedetomidine group(P < 0. 05). Cardiovascular response was small in dexmedetomidine group and fentanyl group (P > 0. 05). Cardiovascular response was large in control group(P < 0. 05). There were 3 patients with restlessness in control group and 1 case in fentanyl group. Conclusion Small - dose dexmedetomidine or fentanyl can effectively prevent cardiovascular effects during tracheal extubation.