Dexmedetomidine for Sedation in Patients with Mechanical Ventilation after Oral Cancer Operation

Feng Chaonan; Zhan Ying; Feng Shuquan

Abstract：Objective To compare the efficacy and safety of dexmedetomidine with midazolam in mechanically ventilated patients after oral cancer operation. Methods 30 oral cancer patients with expected mechanical ventilation more than 24 h after radical oral cancer surgery were randomly assigned to Dex group(dexmedetomidine 0. 2~1. 0 μg· kg-1·h-1)and Mid group(midazolam 0. 02~0. 1 mg·kg-1·h-1)in order to achieve mild-to-moderate sedation (RASS score -3~0). Percentage of time to achieve target sedation,incidence of delirium,time of mechanical venti-lation,medication time,extubation time,duration of stay in ICU and adverse events were recorded. Results Time to achieve target sedation was longer in Dex group(P﹤0. 05). Time of mechanical ventilation and extubation time were shorter in Dex group(P﹤0. 05). There were no significant difference in incidence of delirium and duration of stay in ICU between these two groups(P﹥0. 05). Conclusion Dexmedetomidine can prolong percentage of time to achieve target sedation,decrease the dose of fentanyl,shorten time of mechanical ventilation and extubation time. However, dexmedetomidine can induce sinus bradycardia and hypotension,which should be monitored in application.