Effects of Hemoperfusion on Micro-inflammation in Maintenance Hemodialysis Patients

Abstract：Objective To investigate the effects of hemodialysis with hemoperfusion on micro -inflammatory state and Lipoprotein-a( LP-a). Methods 89 patients undergoing maintenance hemodialysis were randomly divid-ed into treatment group( HD+HP group,25 males and 21 females)and control group( HD group,23 males and 20 fe-males). 30 healthy adults were selected as healthy control group. Hypersensitive C-reactive protein( hs-CRP),in-terleukin-6(IL-6),tumor necrosis factor-α(TNF-α),lipoprotein-a(LP-a)were measured before and after treatment. Results Micro-inflammatory state and LP-a disorder were common in MHD group. Hs-CRP,IL-6, TNF-α and LP-a were significantly higher in MHD patients than those in healthy normal controls(P﹤0. 01). Hs-CRP,IL-6,TNF-α and LP-a were significantly higher in control group 12 weeks after hemodialysis(P﹤0. 05). Hs-CRP,IL-6,TNF-α and LP-a decreased significantly in treatment group than those in control group 12 weeks after hemodialysis(P﹤0. 05). Conclusion The micro-inflammatory status and disturbance of LP-a metabolism are common in MHD patients. Hemoperfusion can alleviate micro-inflammatory status and improve LP-a metabolic disorders.