Protective Effect of Salvianolate on Myocardium in Diabetic Rats

Abstract：Objective To explore the protective effect of salvianolate on myocardium in diabetic rats as well as the mechanism of action. Methods 40 male SD rats were randomly divided into model group(n = 30)and control group(n = 10). Intraperitoneal injection of streptozotocin was used for modeling. Successful modeling rats were ran-domly divided into high - dose salvianolate group(n = 10),low - dose salvianolate group(n = 10)and model control group(n = 9). Intraperitoneal injection of streptozotocin lasted for 8 weeks and rats were killed after 10 weeks. Cardiac ultrasound was used to determine cardiac morphology and function indexes. HE staining was used to observe pathomor-phology,and the expression of TGF - β1 was detected by immunohistochemical method. Results Compared with con-trol group,ultrasound indexes decreased significantly,myocardial fiber was in a mess,the expression of TGF - β1 in-creased in model group. Compared with model control group,ultrasound indexes and pathological condition improved, the expression of TGF - β1 decreased,which was more obvious in high - dose group than that in low - dose group(P ﹤0. 05). Conclusion Salvianolate can protect myocardium of diabetic rats,which may relate to decrease expression of TGF - β1 .