Effects of Two Drugs Combination on Plasma Indicators in Patients with Diabetic Nephropathy
Zhu Ling
Li Zhiqiang
Abstract：Objective To investigate the effects of sodium ferulate and valsartan on Plasma endothelin(ET),ni-tric oxide(NO)and urinary albumin excretion rate(UAER)in Patients with diabetic nePhroPathy. Methods 123 Pa-tients with diabetic nePhroPathy were randomly divided into sodium ferulate grouP(grouP A),valsartan grouP(grouP B)as well as combination of sodium ferulate and valsartan grouP(grouP C). Plasma ET,NO and UAER in the three grouPs were measured before and after treatment. Results There was no significant difference among indicators in grouP A,grouP B and grouP C before treatment(P > 0. 05). Plasma ET and UAER were lower(P < 0. 05)and Plasma NO increased after treatment in grouP A and grouP B(P < 0. 05). Plasma ET and UAER were significantly lower(P <0. 01)and Plasma NO significantly increased after treatment in grouP C(P < 0. 01). Conclusion The combination of sodium ferulate and valsartan theraPy can effectively decrease Plasma ET and UAER as well as increase NO in Patients with diabetic nePhroPathy,which can be helPful for the treatment of diabetic nePhroPathy.
Keywords：Sodium ferulateValsartanDiabetic nePhroPathyEndothelial function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 95-97 )