Expression and Clinical Significance of Thyroid Transcription Factor - 1 in Non - small Cell Lung Cancer

Li Bo; Zhao Yanyan; Wu Kaisong

Abstract：Objective To exPlore the exPression and clinical significance of thyroid transcriPtion factor -1(TTF -1)in non - small cell lung cancer(NSCLC). Methods 106 cases of NSCLC tissues(including 39 cases of squamous cell carcinoma,56 cases of adenocarcinoma and 11 cases of adenosquamous carcinoma). Immunohistochemical SP method was used to detect the exPression of TTF - 1 in NSCLC tissues and exPlore the relationshiPs between TTF - 1 and clinicoPathological features in NSCLC. Results TTF - 1 localized in nuclear of lung cancer cells,brownish yellow in color. The Positive exPression rates of TTF - 1 were 91. 1%(51 / 56),90. 9%(10 / 11)and 20. 5%(8 / 39)in adenocarcinoma,adenosquamous carcinoma and squamous cell carcinoma. There were significant differences among them(P < 0. 05). There was a relationshiP between the exPression of TTF - 1 and gender. The Positive exPression rate of TTF - 1 was 86. 2%(25 / 29)in female,which was significantly higher than that in male(57. 1% ,44 / 77)(P <0. 05). However,there was no significant difference among age,TNM stage and tumor differentiation(P > 0. 05). Con-clusion The exPression of TTF - 1 is closely related to gender and Pathological tyPe. The Positive exPression rate of TTF - 1 in adenocarcinoma is significantly higher than that in the other tyPe of NSCLC,which can be used for differen-tial diagnosis.