Effect of Ginsenosides on Protection of Sodium Ferulate in Acute Alcoholism Mice
Abstract：Objective To observe the effect of Ginsenosides on protection of Sodium ferulate in acute alcoholism mice.Method Different groups of mice were daily administered intragastrically with SF (100 mg/kg),SF +GS (50mg/kg),SF+GS (100 mg/kg),and SF+GS (150 mg/kg),respectively,for 12 days.30 minutes after the last administration,the animals were given ethanol (7.11 g/kg) intragastrically.The tolerance time and the lasting time of the loss of righting reflex (LR) were recorded.Malonaldehyde (MDA) content,superoxide dismutase (SOD) and alcohol dehydrogenase (ADH) activity of the liver were assayed.Result Compared with the control group,SF obviously delayed the tolerance time of LR,shortened the lasting time of LR,and increased the hepatic ADH activity.Both the high and the low dose of GS used concomitantly with SF decreased MDA content in liver.Conclusion SF has significant protective effect on acute alcoholism mice,while the combination of SF and GS probably can not enhance the protection of SF against acute alcoholism.
Keywords：alcoholGinsenosidesSodium ferulateMDASODADHacute alcoholism
Publication Date：2008-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 346-349 )