Expression of Multidrug Resistance Gene in Ovarian Cancer
Abstract：To inverstigate the potential drug resistance mechanism and the possible contribution of the multidrug resistance phenotype to chemoresistance in ovarian cancer, the mdr1 gene expression was analyzed by using the RT-PCR technique in 7 cases of normal ovary and 32 cases of ovarian carcinoma. Results showed that mdr1 gene was expressed in 9 cases (28.1%) with ovarian carcinoma,but negative expression in normal ovary tissues was found. The expression of mdr1 gene was associated with histologic type (P＜0.05). The patients with mdr1+ had much higher resistance rate (55.6%) than that of mdr1- cases (8.6%) to chemotherapy. The results suggested that the expression of mdr1 gene might contribute to drug resistance in ovarian carcinomas.
Keywords：Ovarian cancerMultidrug resistance geneExpression
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 80-81 )