The Effect of Dehydroepiandrosterone on Anti-oxidation of Cultured Human Umbilical Vein Endothelial Cell
Abstract：To investigate the effect of dehydroepiandrosterone(DHEA) on anti-oxidation of cultured human umbilical vein endothelial cell(HUVEC), cultured HUVEC were exposed to different concentration of DHEA(1 μmol/L,5 μmol/L,50 μmol/L) in medium. The content of malonldehyde (MDA) and superoxide dismitase (SOD) were measured.Results showed that exposure of the cells to TNF-α decreased the content of SOD and increased the content of MDA comparing to blank group (P＜0.05).Exposure of the cells to DHEA (1 μmol/L,5 μmol/L,50 μmol/L) can respectively increased contents of SOD and decreased contents of MDA (P＜0.05 or P＜0.01). Results indicated that DHEA can enhanced the anti￣oxidation of HUVEC and was considered as an effect of anti-atherosclerosis.
Keywords：DehydroepiandrosteroneEndotheliumMalonaldehydeSuperoxide dismutase
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 76-77 )