The Change of The Plasma TXB2, 6-KETO-PGF1 Alpha and vWF in Cirrhosis with Upper Gastrointestinal Bleeding
Abstract：To explore mechanism and pathophysiologic significance of the upper gastrointestinal bleeding in cirrhotic patients, the plasma thromboxane B2(TXB2),6-Keto-prostaglandin F1 alpha(6-Keto-PGF1 alpha) and von Willebrand factor (vWF) were detected in 40 patients with liver cirrhosis and 10 controls using enzyme-linked immunosorbent assay(ELISA). The results showed that the levels of TXB2 and TXB2/6-Keto-PGF1 alpha ratio in cirrhosis without upper gastrointestinal bleeding were significantly decreased in comparison with controls(P＜0.05), but were markedly increased than that with bleeding (P＜0.05-0.01). The levels of 6-Keto-PGF1 alpha and vWF in cirrhosis without bleeding were much higher than that of controls (P＜0.05-0.01), and were significantly decreased in comparison with bleeding (P＜0.05). The results indicated that there were a strong correlation between the upper gastrointestinal bleeding in cirrhosis and the decrement of TXB2,TXB2/6-Keto-PGF1 alpha ratio and elevation of 6-Keto-PGF1 alpha. The elevation of vWF may reflect the degree of injury in hepatic vascular endothelium and the tendency of upper gastrointestinal bleeding.
Keywords：CirrhosisTXB26-Keto-PGF1 alphavWF
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 74-75,77 )