The Effect of LT-receptor Antagonist to LTB4 and Fn in Pulmonary Fibrosis
Abstract：Forty-five rats were divided into three groups in random controlgroup, untreated model group, ACL-treated group. On experimental Day(Day O),the rats were intratracheally instilled Bleomycin (5 mg/kg)or sterile saline, and then treated with ACL(10mg/kg)or saline until they were killed. At the date of 7th,14th,28th after instillation,fifteen rats of each group were sacrificed, the 1.0 gram lower lobe of left lungs were harvested and jellied for determination of LTB4，the blood was collected for determination of Fn. After BLM instillation,LTB4 of treated group and model group was elevated quickly and peaked at 7th day, then treated group declined notably but model group slowly. Fn of model group was much more elevated than that of other group's, Conclusions: LTB4 acts on an important role in the development of pulmonary fibrosis
Keywords：BleomycinPulmonary fibrosisLeukotrienes
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 36-37 )