Experimental Study of Captopril Inhibiting Intimal Hyperplasia in Ballon Injured Artery
Abstract：To study the effect of Angiotension converting enzyme inhibitorcaptopril on the arterial intimal hyperplasia after ballon injury was administered. Eighteen rabbits were divided into three groups at random; sham-operation (S) group, control(Con) group and captopril(cat) group (each group n=6). Captopril was given to 6 rabbits (10 mg/kg.d-1,po) from 2 days before the right carotid arteries were injured by 3.6 F ballon catheter to 14 days after injury. The control group (6 rabbits) underwent the same balloon injury but no medicine was administered. Results showed:1.Lever of plasma ET1 14 days after injury in Cat group was significantly lower than that of Con group; Con group was significantly higher than that of S Group(P＜0.01,respectively).2.Proliferation Index-PCNA:Con group and Cat group were both higher than that of S group(P＜0.01,respectively); Cat group was significantly lower than that of Con group(P＜0.01,respectively). 3.Mean thickness and extent of lumen stenosis:Cat group was significantly lower than Con group (P＜0.01).Conclusion:Captopril inhibits intimal thickening after ballon injury.
Keywords：CaptoprilEndothelinProliferating cell nuclear antigenIntimal Hyperplasia
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 30-32 )