Exploring shared gene expression and molecular mechanisms of periodontitis and systemic lupus erythematosus
JIA Jun
YANG Rongxia
WU Yunhui
GAO Rui
LIU Xiuju
GUO Lei
PENG Guixue
ZONG Yingrui
Abstract：Objective The aim of this study was to analyze the shared genes and associated molecular mechanisms between periodontitis and SLE by bioinformatics.Methods The periodontitis dataset(GSE16134 and GSE23586)and SLE dataset(GSE50772)were downloaded from the GEO database;the gene modules with the highest scores associated with periodontitis and SLE were screened by WGCNA,respectively,and the two were intersected to obtain co-expressed genes;the co-expressed genes were analyzed by KEGG and GO enrichment analyses;PPI networks were constructed and key genes were further screened using Cytohubba and MCODE plug-ins of Cytoscape software;external datasets GSE10334 and GSE20864 were used for further validation.Results 65 co-expressed genes between periodontitis and SLE were obtained by taking intersections;KEGG enrichment analysis showed results mainly related to natural killer cell-mediated cytotoxic effects and bacterial invasion;GO enrichment analysis mainly focused on activation of multiple immune cells,interleukin 17 and TNF-α production;PPI network construction yielded five key genes(CD48,ITGB2,LAPTM5,ARHGDIB and LCP1).Conclusion The results suggest that the potential shared immune-inflammatory mechanism of periodontitis and SLE is mainly related to immune cells and cytokines(interleukin-17 and tumour necrosis factor),and CD48,ITGB2,LAPTM5,ARHGDIB and LCP1 may be important associated genes between periodontitis and SLE.
Keywords：periodontitissystemic lupus erythematosusbioinformaticsbiological processkey genes
Publication Date：2025-10-28
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：7( 572-578 )