Research advances in biomimetic mineralization-regulated hydrodynamic therapy for dentin hypersensitivity
LIU Xuejian
LI He
QIAO Guinong
ZHANG Zhimin
Abstract：Dentin hypersensitivity(DH)is a prevalent clinical condition in dentistry,primarily attributed to abnormal neurosensory conduction mediated by the hydrodynamic theory.External stimuli acting on exposed dentin tubules(DTs)can elicit transient yet sharp pain.Current treatments mainly aim to alleviate symptoms by regulating dentinal fluid flow through desensitizing agents.However,conventional desensitization methods often suffer from insufficient sealing efficacy and limited durability.Biomimetic remineralizing materials have emerged as promising alternatives due to their sustained occlusion capability and structural similarity to natural dentin.Recent advances in nanotechnology and material science have driven the evolution of traditional remineralization systems toward enhanced permeability and bioadhesiveness.In addition,photothermal-responsive composite materials with both remineralizing and therapeutic functions have been developed.Notably,self-assembling hydrogels have shown great potential in precisely sealing DTs,representing a cutting-edge approach for future desensitization therapies.This review summarizes recent progress in hydrodynamics-regulated biomimetic mineralization strategies for DH management,aiming to inform clinical translation and therapeutic innovation.
Keywords：dentin hypersensitivitydentin tubulebiomimetic mineralizationdesensitization treatment
Publication Date：2025-09-28
Online Publishing Date：2025-10-17(First online date of this platform, not the publication date of the document)
Pages：7( 519-525 )