Construction of animal models of periodontitis
GE Shao-hua
WANG Cai-long
SHANG Ling-ling
Abstract：Periodontitis is the most common chronic inflammatory disease of the oral cavity,which not only leads to periodontal attachment loss,causing tooth mobility and loss,affecting the functions of chewing,aesthetics,and pronunciation,but is also a risk factor for more than 50 systemic diseases,adversely affecting overall health.Therefore,effective prevention and treatment of periodontitis has become an important goal in clinical dentistry,and in-depth study of the pathogenesis of periodontitis and evaluation of new treatment methods are crucial important.Experimental animal models of periodontitis have become an important tool for the aforementioned research.This paper systematically describe the construction methods of periodontitis animal models,including the selection of small and large animal models,as well as modeling techniques such as ligature-induced periodontitis,local injection of lipopolysaccharide in the gingiva,local inoculation of periodontal pathogens in the gingiva,high-sugar diet,and chemical induction models,and discusses the advantages and disadvantages of each method,so as to provide a useful reference for the study of periodontitis.
Keywords：periodontitisanimal modelsmodeling techniquesalveolar bone loss
Publication Date：2025-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 125-131 )