Study on polyethylene glycol-based hydrogel for promoting the healing of oral ulcers
LIN Hua-jun
CHEN Lu-yuan
SUI Wen
CHEN Zhi-hui
ZHAO Ting-ting
YU Cheng-cheng
DUAN Yong-hua
HONG Yong-long
Abstract：AIM:To prepare polyethylene glycol-based hydrogels loaded with dexamethasone acetate and initially explore the efficacy of this system in treating oral ulcers.METHODS:The hydrogels were prepared using aminolysis reaction,and its physical properties were analyzed.The biocompatibility of the hydrogels was evaluated using human gingival fibroblasts through the CCK-8 method and cell viability/death staining.The repair effect of ulcer wounds was evaluated through an in vivo oral ulcer model.RESULTS:The hydrogels exhibited good biosafety,excellent adhesive properties,and mechanical strength both in vitro and in vivo,which could promote the healing of oral ulcer wounds.CONCLUSION:The prepared hydrogels can improve the repair efficacy of oral ulcer wounds and are expected to become a novel material for treating oral ulcers.
Keywords：oral ulcerbiocompatibilitypolyethylene glycoldexamethasonesoft tissue repair
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 690-695 )