Immunomodulatory property of dental pulp stem cells and their prospects in clinical applications
XUAN Kun
WANG Man-yu
LIU An-qi
Abstract：Dental pulp stem cells(DPSCs)are increasingly recognized for their pivotal role in immunotherapy and clinical translation.Their exceptional immunomodulatory and anti-inflammatory capabilities make them promising candidates for immunotherapeutic strategies.This review integrates recent single-cell RNA sequencing data to elucidate the mechanisms by which DPSCs modulate the immune microenvironment and ameliorate immune-related diseases.Additionally,it compiles a comprehensive list of clinical trials registered from 2016 to 2024 that utilize DPSCs for the treatment of systemic diseases,provide insights into the immunomodulatory functions of DPSCs at the single-cell level and their potential for clinical application.
Keywords：dental pulp stem cellsstem cells from human exfoliated deciduous teethimmunomodulationimmunotherapysingle-cell RNA sequencing
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 683-689 )