The role of Th17 and Treg related cytokines of serum and gingival crevicular fluid in patients with chronic periodontitis
CHEN Yuan-sheng
Abstract：AIM:To explore the role of Th17 and Treg related cytokines in patients with chronic periodonti-tis. METHODS:180 subjects were divided into normal control group, mild chronic periodontitis group and severe chronic periodontitis group(n=60).Probing depth(PD),plaque index (PLI),bleeding index (BI),clinical attach-ment loss (AL) in all subjects were examened.The levels of IL-17,IL-23,IL-10 and TGF-β in serum and gingival crevicular fluid(GCF) were measured by ELISA.The correlation of cytokines in serum and GCF with clinical indexes was statistically analyzed. RESULTS:PD, AL, PLI and BI were higher in patients with chronic periodontitis than those in control group(P<0.05);in severe group were higher than in the mild group(P<0.05).The serum IL-17, IL-23 levels were higher in chronic periodontitis patients than those in normal control group(P<0.05), in severe group were higher than in mild group(P<0.05).The levels of IL-10 and TGF-β in serum and GCF were the highest in the mild group,and the lowest in the severe group(P<0.05).Correlation analysis showed that the levels of IL-17 and IL-23 in serum and GCF were positively correlated with PD, AL, PLI and BI values respectively. CONCLU-SIOIN:There is an imbalance of Th17/Treg associated cytokines in patients with chronic periodontitis. IL-17 and IL-23 are closely related to chronic periodontitis.
Keywords：chronic periodontitisTh17TregIL-17IL-23IL-10TGF-β
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 87-90,86 )