Levels of melatonin and IL-1β in gingival crevicular fluid with periodontitis before and after initial therapy
YA Zu-ke
LIN Gui-lan
TAO Ren-chuan
ZENG Qi-xin
LIN Xiao-jie
WU Jia-xuan
Abstract：AIM:To investigate the melatonin and IL-1β levels before and after initial therapy and their re-lationship with clinical parameters of chronic periodontitis. METHODS:The levels of melatonin and IL-1β were de-tected by ELISA,correlation between melatonin,IL-1β and clinical indicators probing depth(PD),bleeding on pro-bing(BOP) and clinical attachment loss(CAL) were analyzed. RESULTS:The level of melatonin before initial thera-py in gingival crevicular fluid was higher than that after therapy(P<0.05). There was a positive correlation between the level of melatonin and both PD and BOP (r =0.465, r =0.736). IL-1β was positively correlated with PD (r=0.350,r=0.541),and melatonin was positively correlated with IL-1β(r=0.442). CONCLUSION:The lev-el of melatonin in gingival crevicular fluid in periodontitis patients is correlated with the severity of periodontitis. Perio-dontal treatment has a significant effect on melatonin expression in gingival crevicular fluid.
Keywords：periodontitismelatonininitial therapyGCFIL-1β
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 83-86 )